bsm-30090M-PACIFIC BLUE [Flow Cytometry]
human HLA-DR/Pacific Blue
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Host: Mouse

Target Protein: HLA class II histocompatibility antigen, DR alpha chain

Clonality: Monoclonal

Isotype: IgG2a/Kappa

Entrez Gene: 3122

Swiss Prot: P01903

Purification: Affinity purified by Protein G

Storage Buffer: 0.01M PBS, 0.5%BSA, 0.02% Proclin300

Storage: Store at 2-8℃. Protect from light. Avoid freezing.

Background:

HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. This molecule is expressed on the surface of various antigen presenting cells such as B lymphocytes, dendritic cells, and monocytes/macrophages, and plays a central role in the immune system and response by presenting peptides derived from extracellular proteins, in particular, pathogen-derived peptides to T cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Aug 2020]

Size: 25T,100T

Concentration: n/a

Applications: FCM(10μl per million cells in 100μl staining volume)

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.